Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.62 |
| ▸ | GAA | P10253 | 9/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | GLA | P06280 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891000 | 0.88 | ALDH1A1 (0.48) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891245 | 0.87 | KDM4E (0.48) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891547 | 0.86 | B3GNT2 (0.48) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891194 | 0.84 | GAA (0.60) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL15282035 | 0.84 | HSD17B10 (0.46) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891057 | 0.83 | MAPT (0.53) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891255 | 0.83 | B3GNT2 (0.44) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL891491 | 0.81 | ALDH1A1 (0.56) | ALDH1A1GAAKDM4EGLAKMT2A | |
| SCHEMBL891385 | 0.78 | B3GNT2 (0.51) | ALDH1A1HSD17B10KDM4EHPGDMAPK1 | |
| SCHEMBL1064027 | 0.78 | B3GNT2 (0.65) | ALDH1A1GAAHSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268273-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2011-01-05 | — | — | EP | claimed |
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2012-04-05 | — | — | US | disclosed |
| EP-2268273-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | TRPC4, TRPC3, TRPC1 | ALDH1A1 4789/4885GAA 4591/4885HSD17B10 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.