Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911889 | 0.85 | CA12 (0.51) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8300078 | 0.85 | MAPT (0.46) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8298942 | 0.80 | TBXA2R (0.44) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8912023 | 0.79 | CA12 (0.49) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8300953 | 0.78 | MAPT (0.45) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8911986 | 0.78 | MAPT (0.42) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8912302 | 0.77 | MAPT (0.42) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8300849 | 0.77 | PDE3B (0.48) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8912821 | 0.76 | PDE3B (0.40) | MAPTLMNAPDE3BPDE3APDE4A | |
| SCHEMBL8912495 | 0.76 | LMNA (0.46) | MAPTLMNANPY1RNPY2RPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |