Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.80 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL316893 | 0.93 | TRPA1 (0.76) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| Carbamic Acid SCHEMBL3371914 | 0.91 | TRPA1 (0.73) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| SCHEMBL12388 | 0.89 | — | — | |
| SCHEMBL29406334 | 0.89 | — | — | |
| Formaldehyde SCHEMBL27665137 | 0.87 | TRPA1 (0.84) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| SCHEMBL1937639 | 0.87 | TRPA1 (0.94) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| SCHEMBL27823792 | 0.87 | TRPA1 (0.94) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| Methane SCHEMBL5950714 | 0.87 | TRPA1 (0.94) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| SCHEMBL28075525 | 0.87 | TRPA1 (0.94) | TRPA1CSNK2A1TP53TDP1ALOX15 | |
| SCHEMBL27803153 | 0.87 | TRPA1 (0.94) | TRPA1CSNK2A1TP53TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681669-A | ORGANIC SOLVENT CONTAINING AN AROMATIC CARBONATE AND DISSOLVED LITHIUM SALT | UBE INDUSTRIES, LTD. (JP) | 1997-10-28 | — | — | US | disclosed |