Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.74 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10193802 | 1.00 | TRPM8 (0.74) | TRPM8TRPV1EPHX1AAK1SMN1; SMN2 | |
| SCHEMBL2628781 | 0.89 | TRPM8 (0.74) | TRPM8TRPV1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14564501 | 0.88 | TRPM8 (0.73) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL5442957 | 0.88 | TRPM8 (0.73) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL10073868 | 0.88 | TRPM8 (0.73) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL14564499 | 0.87 | TRPM8 (0.71) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL891564 | 0.85 | TRPM8 (1.00) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL18241124 | 0.85 | TRPM8 (1.00) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL17208068 | 0.85 | TRPM8 (1.00) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL10155482 | 0.85 | TRPM8 (1.00) | TRPM8TRPV1EPHX1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2012-04-05 | — | — | US | disclosed |
| EP-2268273-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | TRPC4, TRPC3, TRPC1 | TRPM8 7/4885TRPV1 5/4885EPHX1 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.