Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912482 | 0.75 | CYP1A2 (0.43) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL8307668 | 0.71 | PDE3B (0.49) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| Bromide SCHEMBL8307460 | 0.70 | PDE3B (0.48) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL8911980 | 0.65 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| Bromide SCHEMBL8300806 | 0.65 | PDE3B (0.45) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL10353459 | 0.63 | CYP1A2 (0.74) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| Bromide SCHEMBL8300626 | 0.63 | PDE3B (0.43) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL3452908 | 0.63 | LMNA (0.80) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL8912452 | 0.62 | PDE3B (0.43) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL1639562 | 0.62 | PDE3B (0.50) | PDE4APDE4BPDE4CPDE4DSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |