Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838004 | 0.92 | TTR (0.45) | TTRNPC1RAB9ABCAT1KDM4E | |
| SCHEMBL11352725 | 0.87 | TTR (0.54) | TTRNPC1RAB9ABCAT1LMNA | |
| SCHEMBL6841233 | 0.86 | TTR (0.55) | TTRNPC1RAB9AKDM4EMEN1 | |
| Furobufen SCHEMBL30901203 | 0.84 | CYP1A2 (0.58) | TTRNPC1RAB9ABCAT1LMNA | |
| Furobufen SCHEMBL43450 | 0.84 | CYP1A2 (0.58) | TTRNPC1RAB9ABCAT1LMNA | |
| SCHEMBL11552376 | 0.82 | TTR (0.43) | TTRNPC1RAB9ALMNAKDM4E | |
| SCHEMBL10992173 | 0.82 | TTR (0.55) | TTRNPC1RAB9ABCAT1LMNA | |
| SCHEMBL3875921 | 0.81 | TTR (0.54) | TTRNPC1RAB9ABCAT1LMNA | |
| SCHEMBL16581127 | 0.81 | TTR (0.54) | TTRNPC1RAB9ABCAT1LMNA | |
| SCHEMBL11551446 | 0.81 | TTR (0.42) | TTRNPC1RAB9ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686466-A | CHOLINESERASE INHIBITOR; TREATMENT OF SENILE DEMENTIA, ALZHEIMER'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| US-5527800-A | A 4H-PYRROLO(3,2,1-IJ)QUINOLIN-8-YL DERIVATIVE ADMINISTERED FOR THERAPY OR PROPHYLAXIS OF SENILE DEMENTIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |