Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857528 | 0.93 | EPHX1 (0.47) | ACHEADORA1EPHX1TLR4 | |
| SCHEMBL236414 | 0.83 | EPHX1 (0.47) | ACHEADORA1EPHX1TLR4 | |
| SCHEMBL3635575 | 0.83 | EPHX1 (0.47) | ACHEADORA1EPHX1TLR4 | |
| SCHEMBL60343 | 0.83 | EPHX1 (0.47) | ACHEADORA1EPHX1TLR4 | |
| SCHEMBL5276297 | 0.82 | EPHX1 (0.42) | ACHEADORA1EPHX1TLR4 | |
| SCHEMBL15927275 | 0.82 | SLC2A1 (0.37) | ACHEADORA1TLR4PRKACA | |
| SCHEMBL16658584 | 0.81 | PRKACA (0.37) | ACHEADORA1PRKACA | |
| SCHEMBL13943524 | 0.81 | PRKACA (0.37) | ACHEADORA1PRKACA | |
| SCHEMBL14172497 | 0.81 | PRKACA (0.37) | ACHEADORA1PRKACA | |
| SCHEMBL60345 | 0.79 | TLR4 (0.50) | ACHEEPHX1TLR4PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658889-A | ADMINISTERING 5-AMINO-4-IMIDAZLECARBOXAMIDE RIBOSIDE WHICH BINDS ADENOSINE MONOPHOSPHATE SITE OF FRUCTOSE-1,6-DIPHOSPHATASE | GENSIA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0427799-B1 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | GENSIA PHARMA (US) | 1994-11-30 | — | — | EP | disclosed |
| EP-0427799-A4 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | — | 1991-07-24 | — | — | EP | disclosed |
| EP-0427799-A1 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE. | GENSIA PHARMA (US) | 1991-05-22 | — | — | EP | disclosed |
| WO-1990009163-A2 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | GENSIA PHARMACEUTICALS, INC. (US) | 1990-08-23 | — | — | WO | disclosed |