SCHEMBL8913817

SCHEMBL8913817

CCCCCCC(Br)C#N

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LCK P06239 1/20 0.43
PPARD Q03181 1/20 0.43
ZDHHC20 Q5W0Z9 1/20 0.43
ZDHHC2 Q9UIJ5 1/20 0.43
TSHR P16473 2/20 0.40
ZDHHC7 Q9NXF8 1/20 0.39
LMNA P02545 1/20 0.39
DNM1 Q05193 2/20 0.39
THRB P10828 1/20 0.38
OPRM1 P35372 1/20 0.37
GPR84 Q9NQS5 3/20 0.35
FDPS P14324 3/20 0.35
SPHK1 Q9NYA1 1/20 0.35
FFAR1 O14842 1/20 0.35
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11162836 1.00 LCK (0.43) LCKPPARDZDHHC20ZDHHC2TSHR
SCHEMBL5711067 0.98
SCHEMBL1926739 0.90
SCHEMBL7158682 0.87 ALDH1A1 (0.39) TSHR
SCHEMBL7691893 0.79
SCHEMBL7159813 0.78 TSHR (0.37) TSHRMAPT
SCHEMBL8932094 0.77
SCHEMBL24044418 0.77 TSHR (0.46) LCKPPARDZDHHC20ZDHHC2TSHR
SCHEMBL985792 0.77 TSHR (0.46) LCKPPARDZDHHC20ZDHHC2TSHR
SCHEMBL13601912 0.77 TSHR (0.46) LCKPPARDZDHHC20ZDHHC2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210289794-A1 COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE FLAGSHIP PIONEERING INNOVATIONS V, INC. 2021-09-23 US disclosed
US-5693633-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1997-12-02 US disclosed
US-5612360-A AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
US-5571925-A HORMONES INHIBITORS FOR HYPOTENSIVE AGENTS ELI LILLY AND COMPANY (US) 1996-11-05 US disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5563278-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1996-10-08 US disclosed
US-5556981-A Angiotensin II antagonist intermediates ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
EP-0438869-B1 Improvements in and relating to angiotensin II antagonists LILLY CO ELI (US) 1994-12-14 EP disclosed
US-5312936-A Hypotensive agents ELI LILLY AND COMPANY (US) 1994-05-17 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed
US-5073566-A Hypotensive agents ELI LILLY AND COMPANY (US) 1991-12-17 US disclosed
EP-0438869-A1 Improvements in and relating to angiotensin II antagonists ELI LILLY AND COMPANY (US) 1991-07-31 EP disclosed