Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ATIC | P31939 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | AHCY | P23526 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912373 | 0.86 | KDM4E (0.57) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL8913186 | 0.84 | KDM4E (0.57) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL4880307 | 0.81 | KDM4E (0.59) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL938225 | 0.81 | ATIC (0.60) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL13190653 | 0.77 | KDM4E (0.47) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL14547198 | 0.76 | KDM4E (0.79) | KDM4ETDP1TP53MAPTATIC | |
| SCHEMBL13190676 | 0.76 | KDM4E (0.47) | KDM4ETDP1TP53MAPTATIC | |
| Acadesine SCHEMBL10017743 | 0.74 | KDM4E (1.00) | KDM4ETDP1TP53MAPTATIC | |
| Acadesine SCHEMBL2394079 | 0.74 | KDM4E (1.00) | KDM4ETDP1TP53MAPTATIC | |
| Acadesine SCHEMBL7141001 | 0.74 | KDM4E (1.00) | KDM4ETDP1TP53MAPTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658889-A | ADMINISTERING 5-AMINO-4-IMIDAZLECARBOXAMIDE RIBOSIDE WHICH BINDS ADENOSINE MONOPHOSPHATE SITE OF FRUCTOSE-1,6-DIPHOSPHATASE | GENSIA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |