Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912269 | 0.81 | PDE3B (0.39) | P2RX7JAK2NTRK1RETPDGFRB | |
| SCHEMBL8912821 | 0.80 | PDE3B (0.40) | P2RX7PDE3BPDE3APDE4APDE4B | |
| SCHEMBL8911348 | 0.79 | PDE3B (0.39) | P2RX7JAK2NTRK1RETPDGFRB | |
| SCHEMBL8291735 | 0.78 | PDE3B (0.40) | P2RX7PDE3BPDE3APDE4APDE4B | |
| SCHEMBL8912661 | 0.77 | PDE3B (0.38) | P2RX7JAK2NTRK1RETPDGFRB | |
| SCHEMBL8296106 | 0.77 | PDE3B (0.43) | P2RX7PDE3BPDE3APDE4APDE4B | |
| SCHEMBL8914142 | 0.77 | PDE3B (0.37) | P2RX7JAK2NTRK1RETPDGFRB | |
| Bromide SCHEMBL8291044 | 0.76 | PDE3B (0.42) | P2RX7PDE3BPDE3APDE4APDE4B | |
| SCHEMBL8912991 | 0.76 | ALDH1A1 (0.41) | P2RX7MEN1KMT2ACYP1A2HPGD | |
| SCHEMBL8912452 | 0.75 | PDE3B (0.43) | P2RX7JAK2NTRK1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |