SCHEMBL8914915

SCHEMBL8914915

Cc1c(SCCCNCc2ccccc2)ccnc1CSc1nc2ccccc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.51
NPC1 O15118 6/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2D6 P10635 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 2/20 0.51
CYP3A4 P08684 1/20 0.51
AR P10275 2/20 0.47
LMNA P02545 4/20 0.43
KMT2A Q03164 4/20 0.43
MAPT P10636 3/20 0.43
HTT P42858 3/20 0.43
CYP2E1 P05181 1/20 0.43
CYP2C8 P10632 1/20 0.43
CYP2B6 P20813 1/20 0.43
ALDH1A1 P00352 2/20 0.42
NOS3 P29474 1/20 0.42
NOS1 P29475 1/20 0.42
NOS2 P35228 1/20 0.42
MEN1 O00255 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8915535 0.94 RAB9A (0.52) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL8914890 0.88 NPC1 (0.52) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL8915374 0.88 NPC1 (0.52) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL8412992 0.86 NPC1 (0.60) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL7814867 0.84 NPC1 (0.56) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL8914004 0.84 NPC1 (0.58) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL7807341 0.84 NPC1 (0.58) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL9278510 0.84 RAB9A (0.64) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL8915610 0.84 NPC1 (0.52) RAB9ANPC1CYP1A2CYP2D6CYP2C9
SCHEMBL9275547 0.84 RAB9A (0.66) RAB9ANPC1CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616581-A BACTERICIDES YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-04-01 US disclosed
US-5504082-A BACTERICIDE FOR HELICOBACTER, ANTIULCER AGENT, GASTRIC ACIDSUPPRESSOR YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1996-04-02 US disclosed
EP-0644191-A1 PYRIDINE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-03-22 EP disclosed