Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 13/20 | 0.58 |
| ▸ | HTR1B | P28222 | 13/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR1F | P30939 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915068 | 1.00 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8915073 | 1.00 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8205310 | 0.82 | HTR1D (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8205314 | 0.82 | HTR1D (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8187195 | 0.81 | HTR1D (0.60) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL9764575 | 0.81 | MAPT (0.63) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL9764568 | 0.81 | MAPT (0.63) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL7013891 | 0.81 | HTR1D (0.66) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8915192 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8209801 | 0.80 | HTR1D (0.58) | CYP1A2CYP3A4CYP2D6CYP2C9THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |