Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.58 |
| ▸ | HTR1B | P28222 | 7/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR1F | P30939 | 2/20 | 0.51 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205314 | 0.87 | HTR1D (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8205310 | 0.87 | HTR1D (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7710792 | 0.87 | HTR1D (0.67) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8187195 | 0.86 | HTR1D (0.60) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7020706 | 0.85 | HTR1D (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7489712 | 0.82 | HTR1D (0.58) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8185092 | 0.81 | HTR1D (0.57) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7013891 | 0.81 | HTR1D (0.66) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7478910 | 0.80 | CYP1A2 (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL25072243 | 0.80 | MTNR1A (0.65) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000000490-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |