SCHEMBL8915124

SCHEMBL8915124

O=[N+]([O-])c1cc(CO)c(Cl)cc1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ALDH1A1 P00352 6/20 0.41
HIF1A Q16665 1/20 0.41
MAPT P10636 2/20 0.40
VCAM1 P19320 2/20 0.39
GPR35 Q9HC97 2/20 0.39
RAB9A P51151 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ESPL1 Q14674 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 1/20 0.38
NPC1 O15118 1/20 0.38
CYP3A4 P08684 1/20 0.38
POLB P06746 1/20 0.38
CA1 P00915 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17543457 0.87 ATM (0.40) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL29859749 0.87 ATM (0.40) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL10713293 0.84 ALDH1A1 (0.46) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL4309305 0.84 TDP1 (0.46) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL6491643 0.84 ALDH1A1 (0.49) ALDH1A1VCAM1GPR35TSHRMAPK1
SCHEMBL29644788 0.83 TDP1 (0.42) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL4276693 0.82 CYP1A2 (0.49) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL10714238 0.81 TDP1 (0.41) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL9614679 0.81 ATM (0.38) ATMTDP1ALDH1A1HIF1AMAPT
SCHEMBL30040804 0.80 TDP1 (0.46) ATMTDP1ALDH1A1HIF1AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5700761-A PREEMERGENCE, POSTEMERGENCE HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-12-23 US disclosed
EP-0745084-A1 HERBICIDAL TRICYCLIC HETEROCYCLES AND BICYCLIC UREAS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-12-04 EP disclosed
WO-1995022547-A1 HERBICIDAL TRICYCLIC HETEROCYCLES AND BICYCLIC UREAS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-08-24 WO disclosed
US-4846882-A HALOBENZYL DERIVATIVES FMC CORPORATION (US) 1989-07-11 US disclosed
WO-1987007602-A2 N-(5-SUBSTITUTED METHYLENE) PHENYL HERBICIDES RHONE-POULENC AGROCHIMIE (FR) 1987-12-17 WO disclosed
CN-87100152-A The compound of weeding 1987-08-12 CN disclosed
WO-1987004049-A1 N-SUBSTITUTED TETRAHYDROPHTHALIMIDE HERBICIDAL COMPOUNDS AND INTERMEDIATES THEREFOR FMC CORPORATION (US) 1987-07-16 WO disclosed