Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398520 | 1.00 | MEN1 (0.44) | MEN1KMT2AHTR2CSLC6A2SLC6A4 | |
| SCHEMBL7865180 | 0.83 | HTR2C (0.40) | HTR2CSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL8921573 | 0.80 | AKR1C3 (0.42) | MEN1KMT2AKDM4E | |
| SCHEMBL8921576 | 0.80 | AKR1C3 (0.42) | MEN1KMT2AKDM4E | |
| SCHEMBL8398502 | 0.80 | HTR2C (0.47) | MEN1KMT2AHTR2CSLC6A2SLC6A4 | |
| SCHEMBL8981783 | 0.77 | DDB1 (0.36) | MEN1KMT2AHTR2CSLC6A2SLC6A4 | |
| SCHEMBL8981779 | 0.77 | DDB1 (0.36) | MEN1KMT2AHTR2CSLC6A2SLC6A4 | |
| SCHEMBL8921930 | 0.76 | SLC18A3 (0.40) | MEN1KMT2AHTR2CDRD2KDM4E | |
| SCHEMBL8921925 | 0.76 | SLC18A3 (0.40) | MEN1KMT2AHTR2CDRD2KDM4E | |
| SCHEMBL16392349 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0711283-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003281-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-02-02 | — | — | WO | disclosed |