Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12084116 | 0.89 | CHRM4 (0.52) | OPRL1OPRM1OPRK1GAASMN1; SMN2 | |
| SCHEMBL11474189 | 0.88 | SMN1; SMN2 (0.49) | OPRL1OPRM1OPRK1GAASMN1; SMN2 | |
| SCHEMBL12084485 | 0.87 | OPRL1 (0.69) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL4979950 | 0.84 | OPRK1 (0.49) | OPRL1OPRM1OPRK1MAPTALDH1A1 | |
| SCHEMBL4979947 | 0.84 | OPRK1 (0.49) | OPRL1OPRM1OPRK1MAPTALDH1A1 | |
| SCHEMBL4981374 | 0.83 | OPRL1 (0.55) | OPRL1OPRM1OPRK1MAPTALDH1A1 | |
| SCHEMBL4981373 | 0.83 | OPRL1 (0.55) | OPRL1OPRM1OPRK1MAPTALDH1A1 | |
| SCHEMBL8359815 | 0.83 | OPRL1 (0.55) | OPRL1OPRM1OPRK1GAAMAPT | |
| SCHEMBL8325722 | 0.83 | OPRL1 (0.55) | OPRL1OPRM1OPRK1GAAMAPT | |
| SCHEMBL12084491 | 0.81 | OPRL1 (0.49) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |