Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | YES1 | P07947 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3689655 | 0.92 | KDM4E (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL8916363 | 0.91 | KMT2A (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL8918905 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL3689010 | 0.84 | KMT2A (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL3685595 | 0.80 | KDM4E (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL14133179 | 0.74 | MEN1 (0.59) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL13020366 | 0.74 | SRC (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL8226027 | 0.72 | SRC (0.51) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL13148300 | 0.71 | SRC (0.59) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL3715216 | 0.70 | SRC (0.67) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593997-A | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |