Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 5/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915517 | 0.88 | HTR1B (0.51) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8914437 | 0.87 | HTR1B (0.49) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8917681 | 0.87 | HTR1B (0.49) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8914599 | 0.86 | HTR1B (0.44) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8913747 | 0.86 | HTR1B (0.59) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL9034392 | 0.86 | HTR1B (0.52) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL9394185 | 0.85 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8921687 | 0.85 | GABRP (0.46) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8914697 | 0.85 | HTR1B (0.51) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8917243 | 0.85 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |