Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129676 | 0.76 | HPGD (0.79) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL252026 | 0.76 | HPGD (0.79) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL31435878 | 0.76 | HPGD (0.61) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| SCHEMBL28874149 | 0.76 | HPGD (0.61) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| SCHEMBL9928309 | 0.76 | HPGD (0.61) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| SCHEMBL471434 | 0.76 | CRBN (0.47) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| Hydrochloric Acid SCHEMBL1597472 | 0.74 | HPGD (0.76) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL6233435 | 0.73 | HPGD (0.58) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| SCHEMBL8503467 | 0.73 | HPGD (0.58) | HPGDSIGMAR1CHRM2CHRM3CRBN | |
| SCHEMBL3977397 | 0.73 | HPGD (0.58) | HPGDSIGMAR1CHRM2CHRM3CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |