Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 11/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15883052 | 0.76 | AHR (0.34) | P2RX4AHR | |
| SCHEMBL16523549 | 0.75 | — | — | |
| SCHEMBL17809829 | 0.69 | ALDH1A1 (0.38) | SMN1; SMN2KDM4EMAPK1ATM | |
| SCHEMBL4501683 | 0.68 | P2RX4 (0.36) | P2RX4NPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL2039172 | 0.68 | FGFR1 (0.42) | P2RX4MAPK1 | |
| SCHEMBL14454865 | 0.67 | P2RX4 (0.36) | P2RX4NPSR1MAPTSMN1; SMN2AHR | |
| SCHEMBL18770825 | 0.65 | POLB (0.52) | P2RX4NPSR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL30867065 | 0.65 | POLB (0.52) | P2RX4NPSR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL14244249 | 0.65 | P2RX4 (0.47) | P2RX4NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL31414163 | 0.65 | P2RX4 (0.47) | P2RX4NPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624929-A | Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds | PFIZER INC. (US) | 1997-04-29 | — | — | US | disclosed |
| US-5403839-A | Antiinflammatory agents; arthritis; respiratory system disorders | PFIZER INC (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1989008654-A1 | PYRROLOQUINOLINE AND PYRROLOPHENOTHIAZINE CARBOXAMIDES AND RELATED COMPOUNDS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332364-A2 | Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |