SCHEMBL8918548

SCHEMBL8918548

CC(C)C(c1ccc([N+](=O)[O-])cc1)n1ccnc1

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.69
CYP17A1 P05093 4/20 0.59
CYP26A1 O43174 4/20 0.52
CYP3A4 P08684 1/20 0.52
CYP11B1 P15538 3/20 0.49
CYP11B2 P19099 3/20 0.49
KMT2A Q03164 1/20 0.45
IDO1 P14902 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9662303 0.85 CYP19A1 (0.73) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1
SCHEMBL9190551 0.82 CYP19A1 (0.50) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1
Nitric Acid SCHEMBL8916910 0.82 CYP17A1 (0.66) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1
SCHEMBL4056684 0.81 CYP19A1 (0.47) CYP19A1CYP17A1CYP26A1CYP3A4KMT2A
SCHEMBL4056672 0.81 CYP19A1 (0.47) CYP19A1CYP17A1CYP26A1CYP3A4KMT2A
SCHEMBL4056679 0.81 CYP19A1 (0.47) CYP19A1CYP17A1CYP26A1CYP3A4KMT2A
SCHEMBL9728006 0.77 CYP17A1 (0.47) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1
SCHEMBL4054853 0.77 CYP17A1 (0.68) CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2
SCHEMBL6868753 0.77 CYP19A1 (0.89) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1
SCHEMBL19999188 0.75 CYP19A1 (0.69) CYP19A1CYP17A1CYP26A1CYP3A4CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5612354-A CONTROLLING CELL GROWTH AND DIFFERENTIATION, RETINOIC ACID METABOLISM JANSSEN PHARMACEUTICA N.V. (BE) 1997-03-18 US disclosed
US-5441954-A Treatment of disorders characterized by increased proliferation and/or abnormal differentiation of cells JANSSEN PHARMACEUTICA N. V. (BE) 1995-08-15 US disclosed
EP-0371564-B1 (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-07-12 EP disclosed
US-5268380-A Therapy for keratinization in mammals JANSSEN PHARMACEUTICA N.V. (BE) 1993-12-07 US disclosed
US-5185346-A Antiandrogenic agents; suppress elimination of retinoids; anticarcinogenic agents HANSSEN PHARMACEUTICA (BE) 1993-02-09 US disclosed
EP-0371564-A2 (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1990-06-06 EP disclosed