Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorobenzene SCHEMBL10576700 | 0.92 | CYP17A1 (0.48) | CYP17A1CYP19A1CYP11B1CYP11B2HTT | |
| SCHEMBL10580748 | 0.89 | CYP19A1 (0.48) | CYP17A1CYP19A1CYP11B1CYP11B2HTT | |
| SCHEMBL10582410 | 0.87 | MAPT (0.46) | CYP17A1CYP19A1CYP11B1CYP11B2HTT | |
| SCHEMBL9190551 | 0.83 | CYP19A1 (0.50) | CYP17A1CYP19A1CYP11B1CYP11B2CYP26A1 | |
| SCHEMBL10577494 | 0.83 | CYP17A1 (0.48) | CYP17A1CYP11B1CYP11B2HTTCYP3A4 | |
| SCHEMBL10581964 | 0.82 | CYP19A1 (0.55) | CYP17A1CYP19A1CYP11B1CYP11B2CYP26A1 | |
| SCHEMBL10698157 | 0.82 | MAPT (0.46) | CYP17A1CYP19A1HTTCYP26A1CYP3A4 | |
| SCHEMBL9728217 | 0.80 | CYP17A1 (0.45) | CYP17A1CYP11B1CYP11B2HTTCYP26A1 | |
| SCHEMBL9196029 | 0.80 | L3MBTL1 (0.51) | CYP17A1CYP11B1CYP11B2HTTCYP26A1 | |
| SCHEMBL9191000 | 0.80 | CYP17A1 (0.44) | CYP17A1CYP19A1CYP11B1CYP11B2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |