Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917545 | 0.86 | IKBKB (0.80) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| Chs-828 SCHEMBL810990 | 0.86 | IKBKB (0.80) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| Chs-828 SCHEMBL16312347 | 0.86 | IKBKB (0.80) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| SCHEMBL8918236 | 0.86 | IKBKB (0.80) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| Chs-828 SCHEMBL12083293 | 0.86 | IKBKB (0.80) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| SCHEMBL8916902 | 0.85 | IKBKB (0.64) | IKBKBNAMPTCYP3A4CYP2D6CYP2C9 | |
| Chs-828 SCHEMBL7142976 | 0.85 | IKBKB (0.79) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| Chs-828 SCHEMBL7148798 | 0.85 | IKBKB (0.79) | IKBKBGAANAMPTCYP3A4CYP2D6 | |
| SCHEMBL14212482 | 0.83 | IKBKB (0.59) | IKBKBPOLBNAMPTCYP3A4CYP2D6 | |
| SCHEMBL14212491 | 0.83 | IKBKB (0.58) | IKBKBTP53NAMPTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |