Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284840 | 0.90 | PDE3B (0.52) | PDE3BPDE3ADRD4MAPK14MEN1 | |
| SCHEMBL8917647 | 0.87 | MEN1 (0.46) | DRD4MAPK14MEN1KMT2AGRIN2D | |
| Hydrochloric Acid SCHEMBL8921537 | 0.85 | PDE3B (0.53) | PDE3BPDE3AMEN1KMT2ARAB9A | |
| SCHEMBL8919087 | 0.85 | DRD4 (0.42) | DRD4MEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7471638 | 0.85 | MEN1 (0.46) | DRD4MAPK14MEN1KMT2ANPC1 | |
| SCHEMBL8920236 | 0.84 | DRD4 (0.41) | DRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8922159 | 0.84 | MEN1 (0.43) | DRD4MAPK14MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8919208 | 0.84 | DRD4 (0.41) | DRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8918884 | 0.83 | MAPK14 (0.51) | MAPK14MEN1KMT2ANPC1GRIN2D | |
| Hydrochloric Acid SCHEMBL8919801 | 0.83 | MEN1 (0.42) | DRD4MAPK14MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |