Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.42 |
| ▸ | HRH2 | P25021 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915168 | 0.82 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HRH4 | |
| SCHEMBL7430606 | 0.82 | POLB (0.53) | SMN1; SMN2HRH4HRH2HRH1CASP3 | |
| SCHEMBL8921944 | 0.81 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1HRH4 | |
| SCHEMBL8918934 | 0.79 | HRH4 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1HRH4 | |
| SCHEMBL8918937 | 0.79 | HRH4 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1HRH4 | |
| SCHEMBL7359985 | 0.73 | KCNJ11 (0.40) | ALDH1A1HDAC4MAPTHTT | |
| SCHEMBL7359989 | 0.73 | KCNJ11 (0.40) | ALDH1A1HDAC4MAPTHTT | |
| SCHEMBL7359997 | 0.73 | KCNJ11 (0.40) | ALDH1A1HDAC4MAPTHTT | |
| SCHEMBL3408797 | 0.70 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1CASP3 | |
| SCHEMBL29858769 | 0.70 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |