Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.48 |
| ▸ | HRH2 | P25021 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 3/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 8/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918934 | 1.00 | HRH4 (0.48) | HRH4HRH2HRH1HRH3NPC1 | |
| SCHEMBL8915487 | 0.84 | NAMPT (0.56) | HRH4HRH2HRH1HRH3NPC1 | |
| SCHEMBL8915165 | 0.82 | NAMPT (0.52) | NPC1RAB9AQPCTKCNJ11NAMPT | |
| SCHEMBL8915162 | 0.82 | NAMPT (0.52) | NPC1RAB9AQPCTKCNJ11NAMPT | |
| SCHEMBL8915049 | 0.82 | NAMPT (0.57) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL7430610 | 0.82 | HRH4 (0.52) | HRH4HRH2QPCTKCNJ11NAMPT | |
| SCHEMBL8921940 | 0.81 | NAMPT (0.57) | NPC1RAB9AQPCTKCNJ11NAMPT | |
| SCHEMBL8921935 | 0.81 | NAMPT (0.57) | NPC1RAB9AQPCTKCNJ11NAMPT | |
| SCHEMBL8918941 | 0.79 | NPC1 (0.54) | HRH4HRH2HRH1HRH3NPC1 | |
| SCHEMBL8916218 | 0.75 | NAMPT (0.58) | HRH4HRH2HRH1HRH3QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |