Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.56 |
| ▸ | BACE1 | P56817 | 6/20 | 0.51 |
| ▸ | PYGL | P06737 | 7/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | NR0B2 | Q15466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8997537 | 0.89 | APP (0.59) | APPBACE1PYGLKDRHDAC1 | |
| SCHEMBL798603 | 0.76 | TTR (0.57) | APPMAOBPTGS2 | |
| SCHEMBL798602 | 0.76 | TTR (0.57) | APPMAOBPTGS2 | |
| SCHEMBL10747246 | 0.74 | MEN1 (0.60) | MAOB | |
| SCHEMBL3223964 | 0.72 | BACE1 (0.88) | APPBACE1PYGLHDAC1HDAC8 | |
| SCHEMBL3223975 | 0.72 | BACE1 (0.88) | APPBACE1PYGLHDAC1HDAC8 | |
| SCHEMBL585531 | 0.72 | APP (0.60) | APP | |
| SCHEMBL585530 | 0.72 | APP (0.60) | APP | |
| SCHEMBL5219928 | 0.72 | HDAC1 (0.53) | APPBACE1KDRHDAC1HDAC8 | |
| SCHEMBL11684209 | 0.72 | CYP1A2 (0.65) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670525-A | Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |