Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 4/20 | 0.48 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918964 | 0.89 | APP (0.56) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL5219928 | 0.84 | HDAC1 (0.53) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL5219915 | 0.84 | HDAC1 (0.53) | APPKDRHDAC6HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL6821851 | 0.82 | HDAC1 (0.52) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL6821842 | 0.81 | KDR (0.53) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL6821848 | 0.81 | KDR (0.53) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL6821093 | 0.79 | APP (0.54) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL6821096 | 0.79 | APP (0.54) | APPKDRHDAC6HDAC1HDAC8 | |
| SCHEMBL31528754 | 0.78 | HDAC1 (0.58) | KDRHDAC6HDAC1HDAC8BACE1 | |
| SCHEMBL9005492 | 0.77 | HDAC1 (0.50) | APPKDRHDAC6HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559139-A | ANTIISCHEMIC AGENTS, MICROCIRCULATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |