Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | TOP1 | P11387 | 4/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TOP2A | P11388 | 10/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9045570 | 0.99 | KMT2A (0.71) | KMT2ATOP1GSK3BEPHA2FLT4 | |
| SCHEMBL10530683 | 0.90 | LMNA (0.69) | KMT2ATOP1GSK3BLMNAMEN1 | |
| Hydrochloric Acid SCHEMBL10528341 | 0.90 | LMNA (0.70) | KMT2ATOP1GSK3BLMNAMEN1 | |
| SCHEMBL17359841 | 0.89 | LMNA (0.59) | KMT2ATOP1GSK3BEPHA2FLT4 | |
| SCHEMBL10530660 | 0.87 | TOP1 (0.68) | KMT2ATOP1LMNAMEN1KDM4E | |
| SCHEMBL8138991 | 0.87 | KMT2A (0.59) | KMT2ATOP1GSK3BLMNAMEN1 | |
| SCHEMBL8925616 | 0.87 | KMT2A (0.56) | KMT2ATOP1GSK3BEPHA2FLT4 | |
| SCHEMBL8926571 | 0.87 | KMT2A (0.56) | KMT2ATOP1GSK3BEPHA2FLT4 | |
| SCHEMBL8925611 | 0.87 | KMT2A (0.56) | KMT2ATOP1GSK3BEPHA2FLT4 | |
| SCHEMBL8137032 | 0.87 | KMT2A (0.59) | KMT2ATOP1GSK3BLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672600-A | Antimicrobial dithiocarbamoyl quinolones | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0360258-B1 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LAB (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5387748-A | Antimicrobial dithiocarbamoyl quinolones | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5057520-A | Water solubility | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| US-5057523-A | Water soluble bactericide | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| US-4962112-A | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds | ABBOTT LABORATORIES (US) | 1990-10-09 | — | — | US | disclosed |
| WO-1990004591-A1 | NOVEL ANTIMICROBIAL DITHIOCARBAMOYL QUINOLONES | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1990-05-03 | — | — | WO | disclosed |
| EP-0366643-A2 | Novel antimicrobial dithiocarbamoyl quinolones | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0360258-A2 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LABORATORIES (US) | 1990-03-28 | — | — | EP | disclosed |
| EP-0302371-A2 | 7-(2-Methyl-4-aminopyrrolidinyl)naphthyridine and quinoline compounds | ABBOTT LABORATORIES (US) | 1989-02-08 | — | — | EP | disclosed |
| EP-0131839-B1 | QUINOLINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-02-01 | — | — | EP | disclosed |
| US-4762845-A | BACTERICIDES | ABBOTT LABORATORIES (US) | 1988-08-09 | — | — | US | disclosed |
| US-4730000-A | 7-SUBSTITUTED AMINO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND ESTERS | ABBOTT LABORATORIES (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0131839-A1 | Quinoline antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-01-23 | — | — | EP | disclosed |