⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403947 | 0.92 | — | — | |
| SCHEMBL6403950 | 0.92 | — | — | |
| SCHEMBL1485909 | 0.83 | — | — | |
| SCHEMBL24891629 | 0.78 | — | — | |
| SCHEMBL10684430 | 0.74 | — | — | |
| SCHEMBL10684423 | 0.74 | — | — | |
| SCHEMBL401731 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL27489614 | 0.70 | ALDH1A1 (0.35) | — | |
| SCHEMBL27464350 | 0.70 | ALDH1A1 (0.35) | — | |
| SCHEMBL27443379 | 0.70 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382707-A | Biological marker will be to the purposes in the cancer patient for having response with PRMT5 inhibitor for treating in identification | 詹森药业有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-109803971-A | Novel monocyclic and bicyclic substituted carbanucleoside analogs as PRMT5 inhibitors | 詹森药业有限公司 | 2019-05-24 | — | — | CN | disclosed |
| CN-107922413-A | Novel 6-6 bicyclic aromatic ring substituted nucleoside analogs as PRMT5 inhibitors | 詹森药业有限公司 | 2018-04-17 | — | — | CN | disclosed |
| US-5637652-A | MOLDING MATERIALS; POLYPYRROLIDINE, POLYTHIOPHENE, FURAN RESINS, POLYARYLENEVINYLENE, POLYANILINE | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1997-06-10 | — | — | US | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |