Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.76 |
| ▸ | DRD2 | P14416 | 14/20 | 0.76 |
| ▸ | DRD3 | P35462 | 13/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786997 | 0.87 | DRD2 (1.00) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL2334776 | 0.86 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8919044 | 0.85 | DRD4 (0.80) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8916449 | 0.85 | DRD4 (0.84) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8915671 | 0.85 | DRD4 (0.80) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL8915781 | 0.83 | DRD4 (0.77) | DRD4DRD2DRD3CHRM3OPRM1 | |
| SCHEMBL8786461 | 0.81 | DRD2 (0.87) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL9034574 | 0.78 | DRD2 (0.79) | DRD4DRD2DRD3CHRM3OPRM1 | |
| SCHEMBL8788272 | 0.77 | DRD2 (0.77) | DRD4DRD2DRD3CHRM3OPRM1 | |
| SCHEMBL8481456 | 0.77 | DRD4 (0.74) | DRD4DRD2DRD3CHRM3AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698573-A | Imidazolone and oxazolone derivatives as dopamine antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-12-16 | — | — | US | disclosed |
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |