SCHEMBL8920084

SCHEMBL8920084

N#CNC(=NCCNc1ccccc1)Nc1ccncc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 13/20 0.59
QPCT Q16769 3/20 0.57
CYP3A4 P08684 3/20 0.52
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP2D6 P10635 1/20 0.52
P2RX7 Q99572 2/20 0.51
CYP1A2 P05177 1/20 0.47
ALOX15 P16050 1/20 0.47
NFKB1 P19838 1/20 0.47
MAPK1 P28482 1/20 0.47
HIF1A Q16665 1/20 0.47
HSD17B10 Q99714 1/20 0.47
ABCC9 O60706 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
GLA P06280 1/20 0.47
BLM P54132 1/20 0.47
PMP22 Q01453 1/20 0.47
KCNJ11 Q14654 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8918759 0.91 QPCT (0.59) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL8919397 0.80 NAMPT (0.67) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL8915049 0.80 NAMPT (0.57) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL8915411 0.79 NAMPT (0.72) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL810778 0.79 NAMPT (0.65) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL6950783 0.78 NAMPT (0.78) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL810132 0.77 NAMPT (0.80) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL810473 0.77 NAMPT (0.80) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL8054321 0.77 NAMPT (0.80) NAMPTQPCTCYP3A4CYP2C9CYP2C19
SCHEMBL810882 0.77 NAMPT (0.80) NAMPTQPCTCYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5696140-A FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1997-12-09 US disclosed
US-5563160-A NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) 1996-10-08 US disclosed
EP-0660823-B1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS LEO PHARM PROD LTD (DK) 1996-08-14 EP disclosed
EP-0660823-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. LEO PHARM PROD LTD (DK) 1995-07-05 EP disclosed
WO-1994006770-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1994-03-31 WO disclosed