Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196161 | 0.86 | IDO1 (0.43) | NCOA3CYP19A1CYP11B1CYP11B2IDO1 | |
| Sulfuric Acid SCHEMBL9485614 | 0.84 | NCOA3 (0.50) | NCOA3CYP19A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL7455193 | 0.79 | IDO1 (0.39) | CYP19A1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL7463718 | 0.79 | NPC1 (0.44) | CYP11B1CYP11B2IDO1HTR5ARAB9A | |
| SCHEMBL9663760 | 0.77 | CBFB (0.57) | RAB9ANPC1KMT2ALMNAMAPT | |
| SCHEMBL9077581 | 0.77 | IDO1 (0.47) | CYP19A1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL9836179 | 0.77 | IDO1 (0.53) | CYP19A1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL7453705 | 0.77 | HTR5A (0.40) | CYP19A1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL9663508 | 0.77 | IDO1 (0.37) | CYP19A1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL9195882 | 0.77 | HTR5A (0.44) | NCOA3CYP19A1CYP11B1CYP11B2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612354-A | CONTROLLING CELL GROWTH AND DIFFERENTIATION, RETINOIC ACID METABOLISM | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-18 | — | — | US | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |