Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920191 | 1.00 | HPGD (0.38) | HPGDL3MBTL1CYP19A1PRCPNPSR1 | |
| SCHEMBL4867731 | 0.85 | CYP3A4 (0.40) | — | |
| SCHEMBL8924522 | 0.85 | HPGD (0.38) | HPGDL3MBTL1CYP19A1PRCPNPSR1 | |
| SCHEMBL8921189 | 0.85 | HTT (0.40) | HPGDL3MBTL1 | |
| SCHEMBL8921192 | 0.85 | HTT (0.40) | HPGDL3MBTL1 | |
| SCHEMBL4867739 | 0.85 | CYP3A4 (0.40) | — | |
| SCHEMBL8924511 | 0.85 | HPGD (0.38) | HPGDL3MBTL1CYP19A1PRCPNPSR1 | |
| SCHEMBL8920936 | 0.82 | HPGD (0.40) | HPGDL3MBTL1CYP19A1NPSR1SMN1; SMN2 | |
| SCHEMBL8920925 | 0.82 | HPGD (0.40) | HPGDL3MBTL1CYP19A1NPSR1SMN1; SMN2 | |
| SCHEMBL10041960 | 0.79 | SLC6A2 (0.51) | HTR2AHTR2CHTR2BHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |