SCHEMBL8920771

SCHEMBL8920771

CCC=C(C=CC(=O)O)CC

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
TP53 P04637 1/20 0.43
EGLN1 Q9GZT9 1/20 0.43
EGLN3 Q9H6Z9 1/20 0.43
HCAR2 Q8TDS4 7/20 0.41
FFAR3 O14843 1/20 0.35
PPARA Q07869 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.32
ALDH1A1 P00352 2/20 0.32
GAA P10253 1/20 0.32
ALOX15 P16050 1/20 0.32
RECQL P46063 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8920758 1.00 TSHR (0.43) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL30695271 0.82 HCAR2 (0.41) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL30695273 0.82 HCAR2 (0.41) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL13347104 0.82 HCAR2 (0.41) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL9367291 0.80 TSHR (0.47) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL9367295 0.80 TSHR (0.47) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL28413175 0.78 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL11852741 0.78 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL11852735 0.78 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL23795446 0.77 EP300 (0.50) HCAR2PPARAALOX15RECQLHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691366-A UNSATURATED NITRO OXIME FORMED BY REACTION OF DINITROGEN TRIOXIDE WITH DIOLEFIN ETHER, SULFIDE OR AMINE TO BE USED AS VASODILATORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-25 US disclosed
US-5495023-A VASODILATORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-02-27 US disclosed
EP-0612315-A1 NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-08-31 EP disclosed
WO-1993010097-A1 NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-05-27 WO disclosed