Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 4/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.34 |
| ▸ | MGMT | P16455 | 3/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170817 | 0.84 | HPRT1 (0.43) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL16020626 | 0.82 | HPRT1 (0.43) | ADORA2BADORA2AMGMTHPRT1FGFR1 | |
| SCHEMBL8918790 | 0.82 | ADORA2B (0.37) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL216787 | 0.76 | HPRT1 (0.44) | ADORA2BADORA2AHPRT1FGFR1SLC22A6 | |
| SCHEMBL6836084 | 0.76 | HPRT1 (0.35) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL385154 | 0.75 | CDK1 (0.38) | ADORA2BCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL16037341 | 0.74 | CDK1 (0.40) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL2249888 | 0.74 | ADORA2A (0.39) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL15545146 | 0.74 | HPRT1 (0.42) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL669007 | 0.73 | ADORA2B (0.61) | ADORA2BADORA2ACDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696263-A | Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-09 | — | — | US | claimed |
| US-5696263-A | Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-09 | — | — | US | disclosed |