Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2132646 | 0.82 | CTSD (0.59) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL8270781 | 0.82 | CTSD (0.59) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL19419777 | 0.82 | CTSD (0.59) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL17305281 | 0.76 | CTSD (0.56) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL5963417 | 0.76 | CTSD (0.56) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL8920709 | 0.76 | DDB1 (0.45) | CRBNDDB1SRD5A1HPGD | |
| SCHEMBL8922877 | 0.75 | PLG (0.39) | CRBNDDB1PLGPOLBHPGD | |
| SCHEMBL23459341 | 0.75 | CTSD (0.58) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL6970123 | 0.75 | CTSD (0.58) | CRBNDDB1CTSDPOLBTACR2 | |
| SCHEMBL598397 | 0.74 | CTSD (0.54) | CRBNDDB1CTSDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |