Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 9/20 | 0.35 |
| ▸ | TP53 | P04637 | 8/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922067 | 0.91 | PLA2G10 (0.43) | PLA2G10PLA2G5CCKBRCETP | |
| SCHEMBL8923398 | 0.90 | PLA2G10 (0.42) | PLA2G10PLA2G5CCKBRMAPTCETP | |
| SCHEMBL8923886 | 0.90 | CCKBR (0.42) | PLA2G10PLA2G5CCKBRMDM2TP53 | |
| SCHEMBL8921722 | 0.83 | RAMP1 (0.41) | PLA2G10PLA2G5CCKBRMDM2TP53 | |
| SCHEMBL8920178 | 0.80 | CCKBR (0.46) | PLA2G10PLA2G5CCKBR | |
| SCHEMBL8924391 | 0.79 | CCKBR (0.39) | PLA2G10PLA2G5CCKBRTP53MAPT | |
| SCHEMBL8922606 | 0.79 | CCKBR (0.40) | PLA2G10PLA2G5CCKBR | |
| SCHEMBL8921138 | 0.79 | PLA2G10 (0.45) | PLA2G10PLA2G5CCKBRMAPTALDH1A1 | |
| SCHEMBL8921204 | 0.78 | CCKBR (0.60) | CCKBR | |
| SCHEMBL8919257 | 0.77 | CCKBR (0.53) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |