Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 4/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920353 | 1.00 | ECE1 (0.48) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8921886 | 0.90 | ECE1 (0.38) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8921868 | 0.90 | ECE1 (0.38) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8922567 | 0.89 | ECE1 (0.49) | ECE1MMEAGTR2PPARA | |
| SCHEMBL8922631 | 0.89 | ECE1 (0.49) | ECE1MMEAGTR2PPARA | |
| SCHEMBL8924771 | 0.88 | ECE1 (0.36) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8924802 | 0.88 | ECE1 (0.36) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8920411 | 0.86 | ROCK2 (0.38) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8923691 | 0.84 | ROCK2 (0.36) | ECE1MMEAGTR2ROCK2ROCK1 | |
| SCHEMBL8923716 | 0.84 | ROCK2 (0.36) | ECE1MMEAGTR2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | claimed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | claimed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |