Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.51 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622848 | 0.84 | CYP24A1 (0.58) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL8921371 | 0.83 | CYP24A1 (0.54) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL4098450 | 0.82 | CYP24A1 (0.54) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL5217220 | 0.82 | MAPK1 (0.53) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL972021 | 0.79 | CYP24A1 (0.53) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL7290713 | 0.79 | CYP24A1 (0.53) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL4548389 | 0.78 | CYP24A1 (0.55) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL19128297 | 0.77 | CYP24A1 (0.51) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL4548390 | 0.77 | CYP24A1 (0.51) | CYP24A1CYP27A1CYP26A1CYP19A1SMN1; SMN2 | |
| SCHEMBL13039619 | 0.76 | DRD2 (0.60) | CYP24A1CYP27A1CYP26A1CYP19A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |
| WO-1996009293-A1 | BENZ[g]INDAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |