Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 0.47 |
| ▸ | MME | P08473 | 9/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923075 | 0.94 | ECE1 (0.46) | ECE1MMEAGTR2ADORA3ADORA2A | |
| SCHEMBL8923069 | 0.94 | ECE1 (0.46) | ECE1MMEAGTR2ADORA3ADORA2A | |
| SCHEMBL8920316 | 0.91 | ECE1 (0.44) | ECE1MMEAGTR2ADORA3ADORA2A | |
| SCHEMBL8920954 | 0.90 | ECE1 (0.52) | ECE1MMEAGTR2 | |
| SCHEMBL8920944 | 0.90 | ECE1 (0.52) | ECE1MMEAGTR2 | |
| SCHEMBL8921967 | 0.88 | MME (0.46) | ECE1MMEAGTR2 | |
| SCHEMBL8921961 | 0.88 | MME (0.46) | ECE1MMEAGTR2 | |
| SCHEMBL8923159 | 0.86 | MME (0.45) | ECE1MMEAGTR2 | |
| SCHEMBL8923142 | 0.86 | MME (0.45) | ECE1MMEAGTR2 | |
| SCHEMBL8932548 | 0.84 | ECE1 (0.43) | ECE1MMEAGTR2ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996026729-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-09-06 | — | — | WO | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0660840-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES. | CIBA GEIGY AG (CH) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994005677-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-03-17 | — | — | WO | disclosed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |