Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 0.80 |
| ▸ | PPP3CA | Q08209 | 11/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117343 | 0.94 | FKBP1A (0.72) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9118228 | 0.93 | FKBP1A (0.71) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9118725 | 0.93 | FKBP1A (0.80) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9118167 | 0.92 | FKBP1A (0.81) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL1387267 | 0.89 | FKBP1A (1.00) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL8911603 | 0.88 | FKBP1A (0.81) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL8912947 | 0.88 | FKBP1A (0.75) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9116822 | 0.87 | FKBP1A (0.82) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9117772 | 0.86 | FKBP1A (0.80) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9119068 | 0.86 | FKBP1A (0.77) | FKBP1APPP3CAMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767791-A1 | ARYL, ALKYL, ALKENYL AND ALKYNYLMACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO. INC. (US) | 1997-04-16 | — | — | EP | claimed |
| WO-1995035299-A1 | ARYL, ALKYL, ALKENYL AND ALKYNYLMACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-12-28 | — | — | WO | claimed |