SCHEMBL8922203

SCHEMBL8922203

O=C(O)c1ccc(C(c2ccc(C(=O)O)cc2)(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 5/20 0.57
TSHR P16473 2/20 0.50
TP53 P04637 1/20 0.50
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
EPHX2 P34913 1/20 0.45
CYP2C8 P10632 1/20 0.44
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
RARB P10826 1/20 0.43
RARG P13631 1/20 0.43
CA12 O43570 1/20 0.43
CA3 P07451 1/20 0.43
TYR P14679 1/20 0.43
DRD1 P21728 1/20 0.43
CA4 P22748 1/20 0.43
CA6 P23280 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8923492 0.94 SRD5A2 (0.55) SRD5A2TSHRTP53RXRARXRB
SCHEMBL8923504 0.89 PARP15 (0.51) SRD5A2TSHRRXRARXRBRXRG
SCHEMBL336470 0.87 SRD5A2 (0.61) SRD5A2TSHRTP53RXRARXRB
Hydrochloric Acid SCHEMBL19837805 0.85 SRD5A2 (0.59) SRD5A2TSHRTP53RXRARXRB
Hydrochloric Acid SCHEMBL8505603 0.85 SRD5A2 (0.59) SRD5A2TSHRTP53RXRARXRB
SCHEMBL8921736 0.84 PARP15 (0.50) SRD5A2TSHRRXRARXRBRXRG
Perflubutane SCHEMBL28930534 0.84 TSHR (0.63) SRD5A2TSHRTP53RXRARXRB
SCHEMBL1482190 0.83 SRD5A2 (0.57) SRD5A2TSHRTP53RXRARXRB
SCHEMBL9290961 0.82 SRD5A2 (0.55) SRD5A2TSHRTP53RXRARXRB
SCHEMBL9742053 0.82 RXRA (0.59) SRD5A2TSHRTP53RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed
EP-0708149-A1 Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-24 EP disclosed