Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191384 | 0.97 | USP2 (0.32) | USP2CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL9368483 | 0.77 | HTR2A (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL31141328 | 0.77 | FNTA (0.35) | USP2CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL12535828 | 0.77 | FNTA (0.35) | USP2CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL23976185 | 0.75 | CYP19A1 (0.30) | — | |
| SCHEMBL30225188 | 0.75 | CYP19A1 (0.30) | — | |
| SCHEMBL15267544 | 0.72 | HTR2A (0.35) | USP2CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL8264784 | 0.71 | CYP1A2 (0.35) | USP2CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL8054157 | 0.71 | USP2 (0.32) | USP2CYP3A4 | |
| SCHEMBL190840 | 0.70 | ALOX15 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610303-A | MONOAMIDE OXIDASE INHIBITORS | UBE INDUSTRIES, LTD. (JP) | 1997-03-11 | — | — | US | disclosed |