Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.77 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.77 |
| ▸ | PDE2A | O00408 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NT5E | P21589 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | CD99 | P14209 | 1/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923008 | 1.00 | ADORA2A (0.77) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL7038412 | 0.90 | LMNA (0.75) | ADORA2AADORA3ADORA1LMNANT5E | |
| SCHEMBL7038406 | 0.90 | LMNA (0.75) | ADORA2AADORA3ADORA1LMNANT5E | |
| SCHEMBL12667516 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL1897825 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL24233629 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL15544938 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL1897823 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL1897828 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A | |
| SCHEMBL29403114 | 0.89 | ADORA2A (0.80) | ADORA2AADORA3ADORA1PDE2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661136-A | 2-halo-2'-fluoro ARA adenosines as antinoplastic agents | SOUTHERN RESEARCH INSTITUTE (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0595826-A4 | 2'-FLUORO-2-SUBSTITUTED ADENINYL ARABINOSIDES AS ANTI-CANCER AGENTS | SOUTHERN RES INST (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5384310-A | Antitumor | SOUTHERN RESEARCH INSTITUTE (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0595826-A1 | 2'-FLUORO-2-SUBSTITUTED ADENINYL ARABINOSIDES AS ANTI-CANCER AGENTS | Southern Research Institute (US) | 1994-05-11 | — | — | EP | disclosed |
| US-5034518-A | Anticarcinogenic agents | SOUTHERN RESEARCH INSTITUTE (US) | 1991-07-23 | — | — | US | disclosed |