Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.65 |
| ▸ | STING1 | Q86WV6 | 12/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23330896 | 0.81 | GSK3B (0.65) | GSK3BSTING1MEN1KMT2AKDM4E | |
| SCHEMBL23330859 | 0.80 | GSK3B (0.57) | GSK3BSTING1MEN1KMT2AKDM4E | |
| SCHEMBL6788481 | 0.79 | GSK3B (1.00) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13919889 | 0.77 | GSK3B (0.69) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL143904 | 0.77 | GSK3B (1.00) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12814481 | 0.76 | GSK3B (0.57) | GSK3BMEN1KMT2AALDH1A1POLB | |
| SCHEMBL899479 | 0.76 | GSK3B (0.61) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8935203 | 0.74 | GSK3B (0.59) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL8935164 | 0.74 | GSK3B (0.59) | GSK3BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23300728 | 0.74 | GSK3B (0.54) | GSK3BSTING1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |