SCHEMBL8924045

SCHEMBL8924045

COc1c(C)c(C)c(O)c(C)c1CNCCOc1cc(C)c(O)cc1C(C)C

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D P25100 2/20 0.67
ADRA1A P35348 2/20 0.67
ADRA1B P35368 2/20 0.67
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
DRD3 P35462 4/20 0.33
CYP1A2 P05177 1/20 0.33
ADRA2A P08913 1/20 0.33
CYP2D6 P10635 1/20 0.33
PKM P14618 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
HTR2C P28335 1/20 0.33
HRH1 P35367 1/20 0.33
OPRK1 P41145 1/20 0.33
CHRNA4 P43681 1/20 0.33
HIF1A Q16665 1/20 0.33
ADRB2 P07550 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8924776 0.99 ADRA1D (0.66) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8924474 0.85 ADRA1D (0.50) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8924539 0.80 ADRA1D (1.00) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8924695 0.80 ADRA1D (0.81) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL10706857 0.80 ADRA1D (0.48) ADRA1DADRA1AADRA1BNPC1RAB9A
Hydrochloric Acid SCHEMBL8925194 0.79 ADRA1D (0.80) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8924618 0.78 ADRA1D (0.78) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8925193 0.78 ADRA1D (0.78) ADRA1DADRA1AADRA1BNPC1RAB9A
Hydrochloric Acid SCHEMBL8927295 0.78 ADRA1D (0.77) ADRA1DADRA1AADRA1BNPC1RAB9A
SCHEMBL8925691 0.78 ADRA1D (0.77) ADRA1DADRA1AADRA1BDRD3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5624961-A Benzylaminoethoxybenzene derivatives, production thereof and use thereof JAPAN TOBACCO INC. (JP) 1997-04-29 US claimed
EP-0693474-A1 NOVEL BENZYLAMINOETHOXYBENZENE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Toyo Boseki Kabushiki Kaisha (JP) 1996-01-24 EP claimed
US-5624961-A Benzylaminoethoxybenzene derivatives, production thereof and use thereof JAPAN TOBACCO INC. (JP) 1997-04-29 US disclosed
EP-0693474-A1 NOVEL BENZYLAMINOETHOXYBENZENE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Toyo Boseki Kabushiki Kaisha (JP) 1996-01-24 EP disclosed