SCHEMBL8924145

SCHEMBL8924145

CCOC(=O)c1cc(OC)cc(C(=O)CBr)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.49
HPGD P15428 3/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 4/20 0.43
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
HSP90AA1 P07900 1/20 0.43
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
POLB P06746 3/20 0.42
GAA P10253 1/20 0.42
GSK3B P49841 1/20 0.41
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
MAPK1 P28482 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
GABRA2 P47869 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5226239 0.89 CYP1A2 (0.59) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL8922334 0.85 CYP1A2 (0.51) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL8923775 0.84 CYP1A2 (0.50) CYP1A2MAPTNPC1RAB9AALDH1A1
SCHEMBL8925052 0.84 CYP1A2 (0.50) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL8924996 0.82 CYP1A2 (0.49) CYP1A2HPGDMAPTNPC1RAB9A
SCHEMBL8924456 0.81 CYP1A2 (0.47) CYP1A2MAPTNPC1RAB9AALDH1A1
SCHEMBL30020619 0.80 HPGD (0.53) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL7467057 0.78 HPGD (0.47) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL1301427 0.77 CYP1A2 (0.77) CYP1A2HPGDCYP3A4MAPTNPC1
SCHEMBL6202564 0.77 CYP1A2 (0.53) CYP1A2HPGDMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5639770-A SUPEROXIDE INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-06-17 US disclosed
EP-0600092-A1 THIAZOLE DERIVATIVE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-08 EP disclosed