Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083576 | 0.81 | SLC5A2 (0.46) | HTR2AHTR2CHTR2B | |
| SCHEMBL9131857 | 0.81 | KDM1A (0.44) | HTR2AHTR2CHTR2BSLC6A3TAAR1 | |
| SCHEMBL3899634 | 0.81 | LMNA (0.36) | HTR2AHTR2CHTR2BSLC6A3MDM2 | |
| SCHEMBL5704482 | 0.78 | TSHR (0.41) | HTR2AHTR2CHTR2BSLC6A3KDM1A | |
| SCHEMBL8857982 | 0.69 | SLC5A2 (0.35) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL38655763 | 0.68 | KDM4E (0.34) | MEN1KMT2A | |
| SCHEMBL11840470 | 0.68 | TSHR (0.52) | HTR2AHTR2CHTR2BTAAR1 | |
| SCHEMBL7169088 | 0.68 | TDP1 (0.49) | MEN1KMT2A | |
| SCHEMBL15327483 | 0.67 | TAAR1 (0.44) | HTR2AHTR2CHTR2BSLC6A3TAAR1 | |
| SCHEMBL6675608 | 0.67 | SLC5A2 (0.38) | KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614518-A | Morpholine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0730593-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014690-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |