Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.62 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11190636 | 0.91 | DAO (0.60) | DAOMIFGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11187166 | 0.84 | DAO (0.57) | DAOTDP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8925407 | 0.81 | CA1 (0.53) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8924872 | 0.78 | DAO (0.65) | DAOTDP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16767847 | 0.77 | DAO (1.00) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11178624 | 0.76 | KDM4E (0.60) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30740090 | 0.76 | KDM4E (0.60) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3736490 | 0.76 | DAO (0.58) | DAOTDP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8925679 | 0.75 | DAO (0.50) | DAOCHEK1 | |
| SCHEMBL8875110 | 0.74 | DAO (0.81) | DAOGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | claimed |
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |